ABOUT OXBRYTA: VIDEO TRANSCRIPT

NARRATOR:

“What is Oxbryta? Let’s take a closer look to see how Oxbryta works in the red blood cells.”

NARRATOR:

“Oxbryta is the first-of-its-kind medicine that’s FDA-approved for sickle cell patients as young as 4 years old.”

NARRATOR:

“INDICATION

What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older. It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.

OXBRYTA is approved under accelerated approval based on an increase in hemoglobin. Continued approval may depend on verification of clinical benefits in ongoing trials.

IMPORTANT SAFETY INFORMATION

Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.

Please listen to additional important safety information later in the video.”

NARRATOR:

“Oxbryta treats sickle cell at its source by attaching to sickle hemoglobin and interfering at the start of the sickling process.”

NARRATOR:

“Oxbryta attaches to sickle hemoglobin and helps it hold oxygen so that it does not clump together. This helps the red blood cells stay healthy, keep their round shape, and deliver oxygen throughout the body.”

NARRATOR:

“Because Oxbryta impacts this very first step, it can reduce sickling and the breakdown of red blood cells, which is a good thing.”

NARRATOR:

“When fewer red blood cells break down, this can also mean that less bilirubin, the substance that causes yellowing of the eyes and skin, is released into the blood.”

NARRATOR:

“Let’s take an up-close look at how Oxbryta works. Blood smears are one way doctors can monitor the shapes of the red blood cells. The one on the left is a real patient’s blood smear before starting Oxbryta.”

NARRATOR:

“The blood smear on the right is from the same patient after taking Oxbryta as their doctor prescribed for 21 days. Please keep in mind that these images are for illustrative purposes only. Not everyone will respond the same way.”

NARRATOR:

“Remember, because Oxbryta impacts the very first step of the sickling process, it can reduce both sickling and the breakdown of red blood cells, which improves anemia. This helps hemoglobin do its job by keeping red blood cells healthy and round.”

NARRATOR:

IMPORTANT SAFETY INFORMATION

Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:

  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”

NARRATOR:

“Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”

NARRATOR:

“What should I avoid while taking OXBRYTA?

Do not take St. John’s wort during treatment with OXBRYTA.”

NARRATOR:

“What are the possible side effects of OXBRYTA?

OXBRYTA can cause serious side effects, including:

  • Severe skin rash and serious allergic reactions. Treatment with OXBRYTA may cause severe skin reactions and serious allergic reactions. The organs in your body may also be affected, such as your liver, kidneys or lungs, and your blood cells.
  • Stop taking OXBRYTA, and tell your healthcare provider or get emergency medical help right away if you develop any of the following signs or symptoms during treatment:
  • rash
  • hives
  • high temperature (fever)
  • swollen glands (lymph nodes)
  • trouble swallowing
  • shortness of breath (difficult breathing)
  • swelling of your face, around your eyes, lips, or tongue
  • lack of energy and tiredness (fatigue)
  • muscle or joint aches”

NARRATOR:

"The most common side effects of OXBRYTA include:

  • headache
  • nausea or vomiting
  • fever
  • stomach-area (abdominal) pain
  • diarrhea
  • rash or hives”

NARRATOR:

“These are not all the possible side effects of OXBRYTA.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Pfizer Inc. at 1-800-438-1985.

Keep OXBRYTA and all medicines out of the reach of children.

For more information, please see full Prescribing Information at Oxbryta.com.”

NARRATOR:

“Imagine less sickling with Oxbryta.”

NARRATOR:

“Talk to your healthcare provider to see if Oxbryta may be right for you or the person with sickle cell you care for. Together, you can decide on the best treatment option.”