LAKESHA: VIDEO TRANSCRIPT

LAKESHA:

“My name is Lakesha. I’m 36 years old. I live in Baton Rouge, Louisiana.”

LAKESHA:

“I am currently a family nurse practitioner. I have one daughter and I’ve been living with sickle cell all my life.”

LAKESHA:

“I love helping people. Ever since I was 16 years old, actually, maybe 12, I knew what I wanted to be. I knew I wanted to be a nurse and I knew I wanted to help people, mainly because I spent a lot of times growing up in hospitals because I was always sick. But I grew up, I became a nurse, and then I saw the Nurse Practitioner role and instantly fell in love with it.”

LAKESHA:

“We grew up, um, didn’t really do many sports. PE as a child for me, um, I could never run like long distances and I was just wondering why I couldn’t breathe, and as an adult, as I grew up in research, did I know it’s the whole, my blood cells didn’t carry oxygen correctly, and so now I know.”

LAKESHA:

“I’m tired, I’m sluggish, I’m achy, I’m hurting. I push on. But the most important thing to me personally was staying out of the hospital. And especially when I had my daughter. There are days when I feel really bad and I don’t want to do anything but just lie in bed, but I know I have to keep moving and pushing for her.”

NARRATOR:

“INDICATION
What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.
It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

“IMPORTANT SAFETY INFORMATION
Do not take OXBRYTA
if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.

LAKESHA:

“As a healthcare provider, I’ve always been on the lookout for more, um, treatments as far as sickle cell and I’ve always been doing research all the time.”

LAKESHA:

“My hemoglobin, after looking at my labs, my hemoglobin my entire life has been between 7.5 and 8.3. Now on Oxbryta, my hemoglobin is about 10.3.”

LAKESHA:

“My reticulocyte count is usually around 10, now my reticulocyte count is three and it, it makes a difference. I don’t feel like my sickle cell has me.”

LAKESHA:

“Patients with sickle cell are often anemic. And, with that anemia you are always cold, you’re tired, sluggish. And, now that I’m on Oxbryta, I am still anemic, but my anemia has improved.”

LAKESHA:

“Now, I still have to watch myself and make sure that I take care of myself. I still have to take frequent breaks. I may not be able to go as hard in the gym as my friend may be able to.”

LAKESHA:

“But, once you get your health in control, then you can rise up and rise to the occasion of being a better you.”

NARRATOR:

“INDICATION
What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.
It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

NARRATOR:

“IMPORTANT SAFETY INFORMATION
Do not take OXBRYTA
if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.
Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:

  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”

NARRATOR:

“Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”

NARRATOR:

“What should I avoid while taking OXBRYTA?
Do not take St. John’s wort during treatment with OXBRYTA.”

NARRATOR:

“What are the possible side effects of OXBRYTA?
OXBRYTA can cause serious side effects, including:

Serious allergic reactions. Tell your healthcare provider or get emergency medical help right away if you get:

  • rash
  • hives
  • shortness of breath (difficult breathing)
  • swelling of the face”

NARRATOR:

“The most common side effects of OXBRYTA include:

  • headache
  • diarrhea
  • stomach-area (abdominal) pain
  • nausea
  • rash or hives
  • fever”

NARRATOR:

“The most common side effects of OXBRYTA in children ages 4 to less than 12 years of age include:

  • fever
  • vomiting
  • rash
  • stomach-area (abdominal) pain
  • diarrhea
  • headache”

NARRATOR:

“These are not all the possible side effects of OXBRYTA.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Global Blood Therapeutics at 1-833-428-4968 (1-833-GBT-4YOU).
Keep OXBRYTA and all medicines out of the reach of children.”