ABOUT OXBRYTA: VIDEO TRANSCRIPT

NARRATOR:

“What is Oxbryta? Let’s take a closer look to see how Oxbryta works in the red blood cells.”

NARRATOR:

“Oxbryta is the first-of-its-kind medicine that’s FDA-approved for sickle cell patients as young as 4 years old.”

NARRATOR:

“INDICATION
What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.
It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

NARRATOR:

“IMPORTANT SAFETY INFORMATION
Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.
Please see additional Important Safety Information throughout and at end of video. For more information, please see full Prescribing Information at Oxbryta.com.”

NARRATOR:

“Oxbryta treats sickle cell at its source by attaching to sickle hemoglobin and interfering at the start of the sickling process.”

NARRATOR:

“Oxbryta attaches to sickle hemoglobin and helps it hold oxygen so that it does not clump together. This helps the red blood cells stay healthy, keep their round shape, and deliver oxygen throughout the body.”

NARRATOR:

“Because Oxbryta impacts this very first step, it can reduce sickling and the breakdown of red blood cells, which is a good thing.”

NARRATOR:

“When fewer red blood cells break down, oxygen delivery can improve. This can also mean that less bilirubin, the substance that causes yellowing of the eyes and skin, is released into the blood.”

NARRATOR:

“Let’s take an up-close look at how Oxbryta works. Blood smears are one way doctors can monitor the shapes of the red blood cells. The one on the left is a real patient’s blood smear before starting Oxbryta.”

NARRATOR:

“The blood smear on the right is from the same patient after taking Oxbryta as their doctor prescribed for 21 days. Please keep in mind that these images are for illustrative purposes only. Not everyone will respond the same way.”

NARRATOR:

“Remember, because Oxbryta impacts the very first step of the sickling process, it can reduce both sickling and the breakdown of red blood cells, which improves anemia. This helps hemoglobin do its job by keeping red blood cells healthy and round so they can deliver oxygen throughout the body.”

NARRATOR:

“Imagine less sickling with Oxbryta.”

NARRATOR:

“Talk to your healthcare provider to see if Oxbryta may be right for you or the person with sickle cell you care for. Together, you can decide on the best treatment option.”

NARRATOR:

“INDICATION
What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.
It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

NARRATOR:

“IMPORTANT SAFETY INFORMATION
Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.
Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:

  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”

NARRATOR:

Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”

NARRATOR:

“What should I avoid while taking OXBRYTA?
Do not take St. John’s wort during treatment with OXBRYTA.”

NARRATOR:

“What are the possible side effects of OXBRYTA?
OXBRYTA can cause serious side effects, including:

Serious allergic reactions. Tell your healthcare provider or get emergency medical help right away if you get:

  • rash
  • hives
  • shortness of breath (difficult breathing)
  • swelling of the face”

NARRATOR:

"The most common side effects of OXBRYTA include:

  • headache
  • diarrhea
  • stomach-area (abdominal) pain
  • nausea
  • rash or hives
  • fever”

NARRATOR:

“The most common side effects of OXBRYTA in children ages 4 to less than 12 years of age include:

  • fever
  • vomiting
  • rash
  • stomach-area (abdominal) pain
  • diarrhea
  • headache”

NARRATOR:

“These are not all the possible side effects of OXBRYTA.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Global Blood Therapeutics at 1-833-428-4968 (1-833-GBT-4YOU).

Keep OXBRYTA and all medicines out of the reach of children.”