NARRATOR:

“This patient is sharing his story in partnership with Pfizer.”

ABRAHAM:

“My name’s Abraham. I’m 27 years old. I’m from a family of seven. It’s a really big family. We believe in family and culture.”

ABRAHAM:

“I live with my siblings right now. I’m also a nursing major.”

NARRATOR:

“INDICATION

What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older. It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.

OXBRYTA is approved under accelerated approval based on an increase in hemoglobin. Continued approval may depend on verification of clinical benefits in ongoing trials.

IMPORTANT SAFETY INFORMATION

Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.

Please listen to additional important safety information later in the video.”

ABRAHAM:

“Living with sickle cell, I know, it’s difficult for me.”

ABRAHAM:

“I learned about Oxbryta from my doctor, from my specialist, I would say.”

ABRAHAM:

“The way my doctor explained how Oxbryta worked, it was very straightforward.”

ABRAHAM:

“So, one of the things Oxbryta really did was reducing my bilirubin levels.”

Abraham:

“And then, my hemoglobin levels also increased.”

ABRAHAM:

“It was where I needed to be.”

ABRAHAM:

“My doctor was kind enough to show me my blood smear pictures, before and after.”

ABRAHAM:

“You could see on the left side, there’s more sickled cells. And on the right side, there were less.”

ABRAHAM:

“It doesn’t really give you super energy or just makes everything absolutely normal. It doesn’t, but what it does, is it takes me closer.”

ABRAHAM:

“I’m hoping my story helps at least one person. This is basically, I call it my biggest secret in the world. And I’m hoping it’ll inspire somebody.”

NARRATOR:

“IMPORTANT SAFETY INFORMATION

Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:

• have liver problems
• are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”

NARRATOR:

“Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”

NARRATOR:

“What should I avoid while taking OXBRYTA?

Do not take St. John’s wort during treatment with OXBRYTA.”

NARRATOR:

“What are the possible side effects of OXBRYTA?

OXBRYTA can cause serious side effects, including:

• Severe skin rash and serious allergic reactions. Treatment with OXBRYTA may cause severe skin reactions and serious allergic reactions. The organs in your body may also be affected, such as your liver, kidneys or lungs, and your blood cells.

• Stop taking OXBRYTA, and tell your healthcare provider or get emergency medical help right away if you develop any of the following signs or symptoms during treatment:

NARRATOR:

“The most common side effects of OXBRYTA include:

• headache
• nausea or vomiting
• fever
• stomach-area (abdominal) pain
• diarrhea
• rash or hives”

NARRATOR:

“These are not all the possible side effects of OXBRYTA.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Pfizer Inc. at 1-800-438-1985.

Keep OXBRYTA and all medicines out of the reach of children.”