MUYIWA:

“Hi, my name is Muyiwa. Um, I live in Durham, North Carolina, and I’ve been here since I was 11 years old.”

MUYIWA:

“I was originally born in Nigeria. My older sister is two years older than me, and she also has sickle cell.”

MUYIWA:

“We were lucky for the opportunity to be able to come here because I felt like our life depended on it. And, we have these three beautiful children, and I mean, I would give up anything for them. They are my heart. They are the reason I’m still here. They’re the reason I, I do what I do. No matter what I do, I do it for my children.”

MUYIWA:

“So, you know, we had three kids. We found out two of them had sickle cell, and we went through the whole emotions, but we’re still here.”

MUYIWA:

“Sickle cell make us who we are. Sickle cell makes us strong. You know, it makes us weak sometimes. The advice I would give people is just live your life, live your truth.”

NARRATOR:

“INDICATION

What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.

It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.

This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

“IMPORTANT SAFETY INFORMATION

Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.

MUYIWA:

“I remember when my doctor first told me about Oxbryta and he called me into the room and he told me that they were going to start me on this medication, Oxbryta.”

MUYIWA:

“And, my hemoglobin is a 9.5 now. And, my doctor, last time I went, he was talking to me and my you know, family. My sister who also has sickle cell, and he was talking about her hemoglobin is six point something, and I looked at her like, I remember when mine was like that. And I’m grateful. And I’m, I mean, I can’t stretch how grateful I am.”

MUYIWA:

“I remember being in the shower and I remember playing music in the shower. And I remember dancing in the shower. Uh, I would never forget it. And I didn’t realize I was dancing until I got out of the shower. And, I’ve been able to get up, cook, play, you know, I still watch what I do. I don’t go out running. I don’t go out fighting karate, you know, I, I just play, I spend time with my kids.”

MUYIWA:

“My kids are my heart, my kids. Every day. My morning I take my son and my two girls to school. I pick them up, you know, we go out, we eat, we, we do whatever we need to do.”

MUYIWA:

“It shows me that maybe there is hope for my children and I’m just excited to see what the future holds.”

NARRATOR:

“INDICATION

What is OXBRYTA?

OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.

It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.

This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

NARRATOR:

“IMPORTANT SAFETY INFORMATION

Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.

Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:

• have liver problems
• are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”

NARRATOR:

“Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”

NARRATOR:

“What should I avoid while taking OXBRYTA?

Do not take St. John’s wort during treatment with OXBRYTA.”

NARRATOR:

“What are the possible side effects of OXBRYTA?

OXBRYTA can cause serious side effects, including:

Serious allergic reactions. Tell your healthcare provider or get emergency medical help right away if you get:

• rash
• hives
• shortness of breath (difficult breathing)
• swelling of the face”

NARRATOR:

“The most common side effects of OXBRYTA include:

• headache
• diarrhea
• stomach-area (abdominal) pain
• nausea
• rash or hives
• fever”

NARRATOR:

“The most common side effects of OXBRYTA in children ages 4 to less than 12 years of age include:

• fever
• vomiting
• rash
• stomach-area (abdominal) pain
• diarrhea
• headache”

NARRATOR:

“These are not all the possible side effects of OXBRYTA.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Global Blood Therapeutics at 1-833-428-4968 (1-833-GBT-4YOU).

Keep OXBRYTA and all medicines out of the reach of children.”