HOW TO TAKE
OXBRYTA
TULLY & HAJARSisters, artists, and actual Oxbryta patients
ONCE-DAILY OXBRYTA COMES IN DIFFERENT DOSAGE FORMS
Oxbryta 300 mg Tablets for Oral Suspension for patients ages 4 years and older, based on patient’s weight and ability to swallow tablets, which should first be mixed in a room temperature clear drink such as drinking water, clear soda, apple juice, clear electrolyte drinks, clear flavored drinks, or clear sports drink before taking. Do not swallow whole, cut, crush, or chew the tablets for oral suspension.
Oxbryta 300 mg Tablets for patients ages 4 to less than 12 years, based on weight and ability to swallow tablets, which are swallowed whole. Do not cut, crush, or chew the tablets.
Oxbryta 500 mg Tablets for patients ages 12 and up, as well as patients ages 4 to less than 12 who weigh 88 lbs (40 kg) or more,* which are swallowed whole. Do not cut, crush, or chew the tablets.
Based on patient's ability to swallow tablets.
Remember, do not change your dose or stop taking Oxbryta unless your healthcare provider tells you to. Please see Patient Prescribing Information and Instructions for Use for complete information on Dosage and Administration.
OXBRYTA 300 MG TABLETS FOR ORAL SUSPENSION
HOW TO PREPARE
Before you get started, have the following ready:
Teaspoon
Small cup
Room temperature clear drink (For example: drinking water, clear soda, apple juice, clear electrolyte drinks, clear flavored drinks, or clear sports drinks)
The prescribed number of Oxbryta 300 mg Tablets for Oral Suspension, which are light yellow, round shaped, and marked with “300 D” on one side
WATCH NOW
See how Dr Scott prepares Oxbryta 300 mg Tablets for Oral Suspension in this step-by-step video guide.
STEPS FOR PREPARING AND TAKING OR GIVING OXBRYTA 300 MG TABLETS FOR ORAL SUSPENSION
POUR CLEAR DRINK
Visually inspect the pills to ensure it is the correct medication.
Be sure your hands are clean and dry, then pour room temperature clear drink in the cup. Use the table below as a guide for the minimum amount of liquid needed for the prescribed dose. You may add more clear drink if needed to mix the tablets.
| NUMBER OF OXBRYTA 300 MG TABLETS FOR ORAL SUSPENSION | AMOUNT OF CLEAR DRINK |
|---|---|
| 1 | 1 tsp (5 mL) |
| 2 | 2 tsp (10 mL) |
| 3 | 3 tsp (15 mL) |
| 4 | 4 tsp (20 mL) |
| 5 | 5 tsp (25 mL) |
| 7 | 7 tsp (35 mL) |
| 8 | 8 tsp (40 mL) |
ADD TABLET(S)
Add the prescribed number of Oxbryta 300 mg Tablet(s) for Oral Suspension to the cup.
Do not swallow whole, cut, crush, or chew the tablets for oral suspension
SWIRL & WAIT
Swirl the cup until the tablet(s) break down in the drink. Take care not to spill. The tablet(s) will not completely dissolve. You will still see small tablet clumps in the mixture.
If you spill any medicine, clean up the spill. Throw away the rest of the prepared medicine and start again
Wait for 1 to 5 minutes before taking or giving the dose.
SWIRL & DRINK
Swirl the cup again. Take care not to spill. Drink immediately.
If giving to a child, make sure that the child is upright. Give all the prepared medicine to the child immediately
ADD MORE LIQUID & REPEAT
Add 1 or 2 more teaspoons of room temperature clear drink to the cup. This is to mix the leftover medicine and to make sure the full dose is taken. Swirl the cup until all the leftover medicine is mixed, and drink immediately. Repeat this step until all the medicine is taken.
After taking all the medicine, you may drink any type of drink
Be sure to wash the spoon and cup with warm water and soap
Please see Instructions for Use for complete information.
FOR ORAL SUSPENSION
Oxbryta 300 mg Tablets for Oral Suspension Dosing Card
Information about dosing and taking Oxbryta 300 mg Tablets for Oral Suspension.
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"When I grow up, I want to be an actor and an artist."
– HAJAR
Actual Oxbryta patient
Actual Oxbryta patient
OXBRYTA 300 MG TABLETS
STEPS FOR TAKING OXBRYTA 300 MG TABLETS
Visually inspect the pills to ensure it is the correct medication. The Oxbryta 300 mg Tablets are film-coated, light purple to purple, oval shaped, and marked with “G 300” on one side.
Swallow tablets whole once a day or exactly as your healthcare provider tells you.
Do not cut, crush, or chew the tablets
| RECOMMENDED DOSE | NUMBER OF OXBRYTA 300 MG TABLETS |
|---|---|
| 300 mg | 1 |
| 600 mg | 2 |
| 900 mg | 3 |
| 1,200 mg | 4 |
| 1,500 mg | 5 |
| 2,100 mg | 7 |
| 2,400 mg | 8 |
Take with or without food.
STEPS FOR TAKING OXBRYTA 300 MG TABLETS
Oxbryta 300 mg Tablets Dosing Card
Information about dosing and taking Oxbryta 300 mg Tablets.
DOWNLOADOXBRYTA 500 MG TABLETS
STEPS FOR TAKING OXBRYTA 500 MG TABLETS
Visually inspect the pills to ensure it is the correct medication. The Oxbryta 500 mg Tablets are film-coated, light yellow, oval shaped and marked with “GBT 500” on one side.
Swallow tablets whole once a day or exactly as your healthcare provider tells you.
Do not cut, crush, or chew the tablets
| RECOMMENDED DOSE | NUMBER OF OXBRYTA 500 MG TABLETS |
|---|---|
| 1,000 mg | 2 |
| 1,500 mg | 3 |
| 2,000 mg | 4 |
| 2,500 mg | 5 |
Take with or without food.
STEPS FOR TAKING OXBRYTA 500 MG TABLETS
Oxbryta 500 mg Tablets Dosing Card
Information about dosing and taking Oxbryta 500 mg Tablets.
DOWNLOADIMPORTANT INFORMATION ABOUT TAKING OXBRYTA
Keep in mind the tips below when taking either Oxbryta 500 mg Tablets or Oxbryta 300 mg Tablets for Oral Suspension.
- Take Oxbryta exactly as your healthcare provider tells you
- Do not change your dose or stop taking Oxbryta unless your healthcare provider tells you to
- Take the full prescribed dose of Oxbryta 1 time each day
- Your healthcare provider may change your dose if needed
- Your healthcare provider may also prescribe a medicine called hydroxyurea during treatment with Oxbryta
- Take Oxbryta with or without food
- If you miss a dose of Oxbryta or do not take the entire dose of Oxbryta, skip that dose and return to your normal dosing schedule the next day
- Do not take St. John’s wort during treatment with Oxbryta
For full information on how you should take Oxbryta, please see the Patient Prescribing Information and Instructions for Use. If you have any questions, please talk to your healthcare provider.
HOW TO STORE OXBRYTA
Store Oxbryta at 68°F to 86°F (20°C to 30°C)
Oxbryta comes in a child-resistant package
The Oxbryta 300 mg Tablets bottle and Oxbryta 500 mg Tablets bottle each contain a desiccant to help keep your medicine dry (protect it from moisture) and a polyester coil. Do not eat
The Oxbryta 300 mg Tablets for Oral Suspension bottle contains a polyester coil. Do not eat
Keep Oxbryta and all medicines out of the reach of children.
SIGN UP FOR EDUCATIONAL EVENTS ABOUT OXBRYTA
PATIENT EVENTS
IMPORTANT SAFETY INFORMATION AND INDICATION
Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.
Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:
- have liver problems
- are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.
Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.
What should I avoid while taking OXBRYTA?
Do not take St. John’s wort during treatment with OXBRYTA.
What are the possible side effects of OXBRYTA?
OXBRYTA can cause serious side effects, including:
Serious allergic reactions. Tell your healthcare provider or get emergency medical help right away if you get:
- rash
- hives
- shortness of breath (difficult breathing)
- swelling of the face
The most common side effects of OXBRYTA include:
- headache
- diarrhea
- stomach-area (abdominal) pain
- nausea
- rash or hives
- fever
The most common side effects of OXBRYTA in children ages 4 to less than 12 years of age include:
- fever
- vomiting
- rash
- stomach-area (abdominal) pain
- diarrhea
- headache
These are not all the possible side effects of OXBRYTA.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Global Blood Therapeutics at 1-833-428-4968 (1-833-GBT-4YOU).
Keep OXBRYTA and all medicines out of the reach of children.
INDICATION
What is OXBRYTA?
OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.
It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).
Oxbryta®, GBT Source®, GBT Source Solutions® are registered trademarks of Global Blood Therapeutics, Inc., a wholly owned subsidiary of Pfizer Inc. All other trademarks are the property of their respective owners.
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