TULLY:

“Hi, I’m Tully. I’m 17 years old. I am a soon-to-be senior and a soon-to-be junior commissioner of my county. I love learning about the environment and learning about the human body and how it works.”

MAPILLAR:

“My name is Mapillar, and I am the mother of 3 beautiful daughters who all have sickle cell disease. Tully is my oldest.”

NARRATOR:

“INDICATION
What is OXBRYTA?
OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older.
It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
This indication is approved under accelerated approval based on increase in hemoglobin (Hb). Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s).”

“IMPORTANT SAFETY INFORMATION
Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.

MAPILLAR:

“When we heard about Oxbryta and were discussing it with her doctor…for us as a family, that is something we were really interested in seeing how Oxbryta could help Tully increase her hemoglobin level because her hemoglobin tends to run a little low. And so just the increase in hemoglobin and helping to make her body have more healthy red blood cells…we were really interested in that outcome for Tully.”

TULLY:

“Due to the fact that Oxbryta goes straight to the source, I have a high number of healthy red blood cells in my body.”

TULLY:

“I went for my first appointment after starting my Oxbryta journey; I realized that my hemoglobin, it rose.”

TULLY:

“That made me very, very proud because I was very consistent with my medicine.”

MAPILLAR:

“I’m so proud of her. She understands what this medicine is doing for her.”

MAPILLAR:

“Her hemoglobin was now higher than it was. So that was pretty exciting.”

MAPILLAR:

“And her bilirubin it decreased. We were just excited for the increase in hemoglobin, and honestly the bilirubin is an icing on the cake.”

TULLY:

“I realized that some days I do need to rest and I do need to take a break every now and then just to catch my breath and just to get back to being me so I can continue my activities again.”

MAPILLAR:

“You know sickle cell disease is so unpredictable, and with Oxbryta helping her have more red blood cells, we have less unpredictable days, which gives her more time to be, like she said, herself and to do the things that she loves.”

NARRATOR:

“IMPORTANT SAFETY INFORMATION
Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:

• have liver problems
• are pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”

NARRATOR:

“Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”

NARRATOR:

“What should I avoid while taking OXBRYTA?
Do not take St. John’s wort during treatment with OXBRYTA.”

NARRATOR:

“What are the possible side effects of OXBRYTA?
OXBRYTA can cause serious side effects, including:
Serious allergic reactions. Tell your healthcare provider or get emergency medical help right away if you get:

• rash
• hives
• shortness of breath (difficult breathing)
• swelling of the face”

NARRATOR:

“The most common side effects of OXBRYTA include:

• headache
• diarrhea
• stomach-area (abdominal) pain
• nausea
• rash or hives
• fever”

NARRATOR:

“The most common side effects of OXBRYTA in children ages 4 to less than 12 years of age include:

• fever
• vomiting
• rash
• stomach-area (abdominal) pain
• diarrhea
• headache”

NARRATOR:

“These are not all the possible side effects of OXBRYTA.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Global Blood Therapeutics at 1-833-428-4968 (1-833-GBT-4YOU).
Keep OXBRYTA and all medicines out of the reach of children.”