TULLY: VIDEO TRANSCRIPT
“This patient is sharing her story in partnership with Pfizer.”
“Hi, I’m Tully. I’m 17 years old. I am a soon-to-be senior and a soon-to-be junior commissioner of my county. I love learning about the environment and learning about the human body and how it works.”
“My name is Mapillar, and I am the mother of 3 beautiful daughters who all have sickle cell disease. Tully is my oldest.”
What is OXBRYTA?
OXBRYTA is a prescription medicine used for the treatment of sickle cell disease in adults and children 4 years of age and older. It is not known if OXBRYTA is safe and effective in children with sickle cell disease below 4 years of age.
OXBRYTA is approved under accelerated approval based on an increase in hemoglobin. Continued approval may depend on verification of clinical benefits in ongoing trials.
IMPORTANT SAFETY INFORMATION
Do not take OXBRYTA if you or your child have had an allergic reaction to voxelotor or any of the ingredients in OXBRYTA. See the end of the patient leaflet for a list of the ingredients in OXBRYTA.
Please listen to additional important safety information later in the video.”
“When we heard about Oxbryta and were discussing it with her doctor…for us as a family, that is something we were really interested in seeing how Oxbryta could help Tully increase her hemoglobin level because her hemoglobin tends to run a little low. And so just the increase in hemoglobin and helping to make her body have more red blood cells…we were really interested in that outcome for Tully.”
“I went for my first appointment after starting my Oxbryta journey; I realized that my hemoglobin, it rose.”
“That made me very, very proud because I was very consistent with my medicine.”
“I’m so proud of her. She understands what this medicine is doing for her.”
“Her hemoglobin was now higher than it was. So that was pretty exciting.”
“And her bilirubin it decreased. We were just excited for the increase in hemoglobin, and honestly the bilirubin is an icing on the cake.”
“I realized that some days I do need to rest and I do need to take a break every now and then just to catch my breath.”
“IMPORTANT SAFETY INFORMATION
Before taking OXBRYTA, tell your healthcare provider about all of your medical conditions, including if you or your child:
- have liver problems
- re pregnant or plan to become pregnant. It is not known if OXBRYTA can harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if OXBRYTA can pass into your breastmilk and if it can harm your baby. Do not breastfeed during treatment with OXBRYTA and for at least 2 weeks after the last dose.”
“Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how OXBRYTA works. OXBRYTA may also affect how other medicines work and may affect the results of certain blood tests. Keep a list of all your medicines and show it to your healthcare provider.”
“What should I avoid while taking OXBRYTA?
Do not take St. John’s wort during treatment with OXBRYTA.”
“What are the possible side effects of OXBRYTA?
OXBRYTA can cause serious side effects, including:
- Severe skin rash and serious allergic reactions. Treatment with OXBRYTA may cause severe skin reactions and serious allergic reactions. The organs in your body may also be affected, such as your liver, kidneys or lungs, and your blood cells.
- Stop taking OXBRYTA, and tell your healthcare provider or get emergency medical help right away if you develop any of the following signs or symptoms during treatment:
- high temperature (fever)
- swollen glands (lymph nodes)
- trouble swallowing
- shortness of breath (difficult breathing)
- swelling of your face, around your eyes, lips, or tongue
- lack of energy and tiredness (fatigue)
- muscle or joint aches”
“The most common side effects of OXBRYTA include:
- nausea or vomiting
- stomach-area (abdominal) pain
- rash or hives”
“These are not all the possible side effects of OXBRYTA.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Pfizer Inc. at 1-800-438-1985.
Keep OXBRYTA and all medicines out of the reach of children.”